PRKACA

Across TCGA cell cohorts, PRKACA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,527 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKACA-associated GO terms across cancer lineages are Regulation of glycolytic process through fructose-6-phosphate, Negative regulation of glycolytic process through fructose-6-phosphate, and Negative regulation of protein localization to chromatin. Each is linked with PRKACA in more than 19 cancer types. Because this analysis shows association rather than direction, both PRKACA-to-partner and partner-to-PRKACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of glycolytic process through fructose-6-phosphate grouped by PRKACA-low versus PRKACA-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACA→partner) and Y-score (partner→PRKACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of glycolytic process through fructose-6-phosphate →	+0.174	+1.157	<.001	<.001	3	20
STOMACH	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.174	+1.157	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.175	+1.135	<.001	<.001	3	16
STOMACH	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.130	+0.997	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Regulation of protein localization to chromatin →	+0.138	+1.077	<.001	.001	3	15
BREAST	Mitotic chromosome condensation →	+0.181	+0.943	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,527 associations by consensus.

Regulation of glycolytic process through fructose-6-phosphate by PRKACA expression — STOMACH

Explore this box plot interactively →