PRKACA

Across TCGA cell cohorts, PRKACA mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKACA-associated genes across cancer lineages are LCE3D, OR2W5, and GAGE1. Each is linked with PRKACA in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKACA-to-partner and partner-to-PRKACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE3D grouped by PRKACA-low versus PRKACA-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACA→partner) and Y-score (partner→PRKACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LCE3D →	+0.110	+5.000	<.001	.005	3	1
KIDNEY	OR2W5 →	+0.026	+5.000	<.001	.005	3	1
KIDNEY	GAGE1 →	+0.690	+5.000	<.001	.005	3	1
LARGE_INTESTINE	SLC6A19 →	+1.354	+3.302	<.001	.008	3	1
LARGE_INTESTINE	C10orf53 →	+0.011	+3.310	<.001	<.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.016	+2.518	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

LCE3D by PRKACA expression — KIDNEY

Explore this box plot interactively →