PRKAB2

Across TCGA patient cohorts, PRKAB2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAB2-associated genes across cancer lineages are eEF2, eIF4E, and A-Raf_pS299. Each is linked with PRKAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAB2-to-partner and partner-to-PRKAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PRKAB2-low versus PRKAB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAB2→partner) and Y-score (partner→PRKAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.388	+2.999	.008	.035	3	1
UCEC	eIF4E →	+0.197	+3.000	.023	.001	3	1
UCEC	A-Raf_pS299 →	-0.174	-2.807	<.001	.003	3	1
UCEC	ERK2 →	+0.195	+2.459	.014	.019	3	1
UCEC	FoxM1 →	+0.234	+2.321	.028	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.137	-2.105	.007	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eEF2 by PRKAB2 expression — UCEC

Explore this box plot interactively →