PRKAB1

Across TCGA pan-cancer cohorts, PRKAB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRKAB1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PRKAB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKAB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where PRKAB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.311	0.817	.005	28	view →
HNSC	DFS	Median	III,IV	0.915	0.658	<.001	19	view →
CCRCC	OS	Quartile	II,III,IV	0.985	0.104	.024	11	view →
PDAC	OS	Tertile	III,IV	0.968	0.472	.003	11	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PRKAB1–LUAD (DFS)

Open the LUAD breakdown →