PRKAB1

Across TCGA patient cohorts, PRKAB1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAB1-associated genes across cancer lineages are MPP, Endothelial cells, and lymphatic Endothelial cells. Each is linked with PRKAB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAB1-to-partner and partner-to-PRKAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by PRKAB1-low versus PRKAB1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAB1→partner) and Y-score (partner→PRKAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MPP →	+0.031	+3.809	<.001	.018	3	1
UCEC	Endothelial cells →	-0.038	-1.957	.027	.032	3	1
UCEC	lymphatic Endothelial cells →	-0.022	-3.281	.035	.010	3	1
UCEC	mv Endothelial cells →	-0.024	-2.689	.026	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MPP by PRKAB1 expression — STAD

Explore this box plot interactively →