PRKAA2

Across TCGA patient cohorts, PRKAA2 mutation is significantly associated with the RNA expression of many other genes, with 2,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAA2-associated genes across cancer lineages are FKBP4P2, KRTAP1-4, and RPS19BP1. Each is linked with PRKAA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKAA2-to-partner and partner-to-PRKAA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FKBP4P2 grouped by PRKAA2-low versus PRKAA2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAA2→partner) and Y-score (partner→PRKAA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FKBP4P2 →	+0.026	+3.408	.001	.006	3	3
LUSC	KRTAP1-4 →	+0.681	+4.496	<.001	.007	3	3
UCEC	RPS19BP1 →	+0.410	+2.246	<.001	.005	3	3
SKCM	RPL32P32 →	+0.331	+2.063	.002	.004	3	2
UCEC	CDK11B →	+0.406	+2.906	<.001	<.001	3	2
SKCM	PALLD-AS1 →	+0.044	+1.935	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,284 associations by consensus.

FKBP4P2 by PRKAA2 expression — COAD

Explore this box plot interactively →