PRKAA2

Across TCGA cell cohorts, PRKAA2 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKAA2-associated genes across cancer lineages are KRTAP5-11, H2BW2, and CCL7. Each is linked with PRKAA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAA2-to-partner and partner-to-PRKAA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-11 grouped by PRKAA2-low versus PRKAA2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAA2→partner) and Y-score (partner→PRKAA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRTAP5-11 →	+0.069	+4.887	<.001	.009	3	2
BLOOD_Myeloma	H2BW2 →	+0.261	+3.716	<.001	.005	3	1
BLOOD_Myeloma	CCL7 →	+0.194	+3.285	.007	.009	3	1
BLOOD_Myeloma	PLA2G2C →	+0.035	+4.000	.006	.002	3	1
BLOOD_Lymphoma	TMEM190 →	+0.159	+3.584	.001	.007	3	1
BLOOD_Lymphoma	FGF16 →	+0.171	+3.321	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

KRTAP5-11 by PRKAA2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →