PRIMPOL

Across TCGA patient cohorts, PRIMPOL protein abundance is significantly associated with the protein abundance of many other proteins, with 8,443 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PRIMPOL-associated proteins across cancer lineages are HIGD1A, LDB3, and EPS15L1_S108. Each is linked with PRIMPOL in more than 2 cancer types. Because this analysis shows association rather than direction, both PRIMPOL-to-partner and partner-to-PRIMPOL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRIMPOL versus HIGD1A in HNSC, with a Pearson correlation of -0.53.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIMPOL→partner) and Y-score (partner→PRIMPOL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HIGD1A →	-0.654	-0.643	<.001	<.001	3	3
PDAC	LDB3 →	+1.076	+0.538	<.001	<.001	3	3
UCEC	EPS15L1_S108 →	+0.452	+0.510	<.001	<.001	3	3
HNSC	IFI6_S125 →	-1.243	-0.647	<.001	.001	3	2
LSCC	KRT16_S448 →	-1.771	-0.350	.005	<.001	3	2
PDAC	MATK_S501 →	-0.700	-0.700	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,443 associations by consensus.

PRIMPOL vs HIGD1A — HNSC

Explore this scatter interactively →