PRIMPOL

Across TCGA patient cohorts, PRIMPOL mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRIMPOL-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and A-Raf_pS299. Each is linked with PRIMPOL in more than 1 cancer types. Because this analysis shows association rather than direction, both PRIMPOL-to-partner and partner-to-PRIMPOL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PRIMPOL-low versus PRIMPOL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIMPOL→partner) and Y-score (partner→PRIMPOL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+2.459	.041	.019	3	2
UCEC	EGFR_pY1068 →	-0.362	-3.000	<.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.204	-3.169	<.001	.018	3	1
UCEC	FoxM1 →	+0.268	+2.321	.012	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.106	-1.990	.039	.030	3	1
UCEC	Heregulin →	-0.174	-3.308	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by PRIMPOL expression — UCEC

Explore this box plot interactively →