PRIMPOL

Across TCGA cell cohorts, PRIMPOL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,268 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRIMPOL-associated GO terms across cancer lineages are R-loop processing, Mitochondrial DNA repair, and DNA damage tolerance. Each is linked with PRIMPOL in more than 18 cancer types. Because this analysis shows association rather than direction, both PRIMPOL-to-partner and partner-to-PRIMPOL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R-loop processing grouped by PRIMPOL-low versus PRIMPOL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIMPOL→partner) and Y-score (partner→PRIMPOL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	R-loop processing →	+0.117	+1.101	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Mitochondrial DNA repair →	+0.181	+1.280	.003	.003	3	19
LUNG_SCLC	DNA damage tolerance →	+0.106	+0.979	<.001	<.001	3	19
LUNG_NSCLC_LUSC	DNA replication, synthesis of primer →	+0.257	+1.392	<.001	<.001	3	18
LUNG_SCLC	DNA synthesis involved in DNA replication →	+0.110	+1.083	<.001	<.001	2	18
LUNG_SCLC	Translesion synthesis →	+0.092	+0.927	<.001	<.001	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,268 associations by consensus.

R-loop processing by PRIMPOL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →