PRIM2

Across TCGA pan-cancer cohorts, PRIM2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PRIM2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PRIM2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRIM2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where PRIM2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.405	0.826	.002	58	view →
HNSC	DFS	Median	All	0.623	1.000	.003	57	view →
LSCC	OS	Tertile	All	0.940	0.627	<.001	49	view →
UCEC	OS	Median	III,IV	1.000	0.433	.007	24	view →
OV	DFS	Tertile	All	0.804	1.000	.043	4	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PRIM2–CCRCC (DFS)

Open the CCRCC breakdown →