PRIM2

Across TCGA patient cohorts, PRIM2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRIM2-associated genes across cancer lineages are IGFBP2, JNK_pT183_Y185, and STAT3_pY705. Each is linked with PRIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRIM2-to-partner and partner-to-PRIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by PRIM2-low versus PRIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIM2→partner) and Y-score (partner→PRIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.913	-3.000	.015	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.252	-2.986	.009	.037	3	1
UCEC	STAT3_pY705 →	-0.643	-2.999	<.001	.035	3	1
UCEC	Cyclin-E2 →	+0.201	+3.000	.039	.037	3	1
UCEC	JNK2 →	+0.346	+2.817	.002	.036	2	1
UCEC	p38-MAPK_pT180_Y182 →	-0.614	-2.986	.018	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IGFBP2 by PRIM2 expression — UCEC

Explore this box plot interactively →