PRIM2

Across TCGA cell cohorts, PRIM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,665 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRIM2-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Negative regulation of metaphase/anaphase transition of cell cycle, and Negative regulation of chromosome separation. Each is linked with PRIM2 in more than 19 cancer types. Because this analysis shows association rather than direction, both PRIM2-to-partner and partner-to-PRIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by PRIM2-low versus PRIM2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIM2→partner) and Y-score (partner→PRIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic sister chromatid separation →	+0.174	+1.383	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.178	+1.256	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome separation →	+0.178	+1.256	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic sister chromatid separation →	+0.193	+1.121	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Negative regulation of sister chromatid segregation →	+0.193	+1.121	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic sister chromatid segregation →	+0.159	+1.246	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,665 associations by consensus.

Regulation of mitotic sister chromatid separation by PRIM2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →