Across TCGA pan-cancer cohorts, PRIM1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRIM1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PRIM1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PRIM1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where PRIM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.704	0.933	.004	46	view →
LSCC	DFS	Tertile	II,III,IV	0.917	0.545	.002	39	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.333	.007	36	view →
HNSC	OS	Median	II,III,IV	0.990	0.939	.040	4	view →
LUAD	DFS	Quartile	III,IV	1.000	0.464	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PRIM1 tumor-vs-normal RNA expression · all PRIM1 data types