PRICKLE4

Across TCGA patient cohorts, PRICKLE4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,164 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible PRICKLE4-associated GO terms across cancer lineages are Methylation, tRNA metabolic process, and DNA modification. Each is linked with PRICKLE4 in more than 30 cancer types. Because this analysis shows association rather than direction, both PRICKLE4-to-partner and partner-to-PRICKLE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methylation grouped by PRICKLE4-low versus PRICKLE4-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE4→partner) and Y-score (partner→PRICKLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Methylation →	+0.044	+0.441	<.001	<.001	3	31
KIRC	tRNA metabolic process →	+0.038	+0.504	<.001	<.001	3	31
KIRC	DNA modification →	+0.042	+0.433	<.001	<.001	3	30
SCLC	Obsolete histone modification →	+0.087	+1.021	<.001	<.001	3	30
KIRC	Peptidyl-lysine modification →	+0.046	+0.505	<.001	<.001	3	30
SCLC	Epigenetic regulation of gene expression →	+0.068	+0.681	<.001	.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,164 associations by consensus.

Methylation by PRICKLE4 expression — UVM

Explore this box plot interactively →