PRICKLE4

Across TCGA patient cohorts, PRICKLE4 protein abundance is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PRICKLE4-associated genes across cancer lineages are PIGH, SGK2, and MYEF2. Each is linked with PRICKLE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRICKLE4-to-partner and partner-to-PRICKLE4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRICKLE4 versus PIGH in COAD, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE4→partner) and Y-score (partner→PRICKLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PIGH →	+0.464	+0.335	.002	.002	3	1
COAD	SGK2 →	-1.333	-0.594	<.001	<.001	3	1
COAD	MYEF2 →	-1.403	-0.392	.001	.007	3	1
COAD	DHDH →	+1.132	+0.493	<.001	.003	3	1
COAD	PTGES3 →	+0.562	+0.446	<.001	.008	3	1
COAD	FANCE →	+0.739	+0.488	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

PRICKLE4 vs PIGH — COAD

Explore this scatter interactively →