PRICKLE4

Across TCGA cell cohorts, PRICKLE4 mutation is significantly associated with the mutation status of many other genes, with 664 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRICKLE4-associated genes across cancer lineages are FASN, OR8B3, and B3GNT9. Each is linked with PRICKLE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRICKLE4-to-partner and partner-to-PRICKLE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PRICKLE4-low versus PRICKLE4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE4→partner) and Y-score (partner→PRICKLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FASN →	+2.312	+4.120	.004	.004	1	2
BLOOD_Leukemia	OR8B3 →	+6.145	+5.479	<.001	<.001	1	1
BLOOD_Leukemia	B3GNT9 →	+5.560	+4.736	.003	.003	1	1
BLOOD_Leukemia	GET4 →	+4.560	+4.870	<.001	<.001	1	1
BLOOD_Leukemia	PWP2 →	+3.823	+4.430	.001	.001	1	1
BLOOD_Leukemia	MICAL3 →	+2.753	+4.544	.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 664 associations by consensus.

FASN by PRICKLE4 expression — BLOOD_Leukemia

Explore this box plot interactively →