PRICKLE2

Across TCGA pan-cancer cohorts, PRICKLE2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRICKLE2 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRICKLE2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRICKLE2 expression acts as an unfavorable survival marker.

HNSC, PDAC, and LSCC are the cancer types where PRICKLE2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.510	0.945	.009	14	view →
PDAC	DFS	Quartile	II,III,IV	0.378	0.786	.040	12	view →
LSCC	OS	Quartile	II,III,IV	0.822	1.000	.014	11	view →
CCRCC	OS	Median	All	0.754	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRICKLE2–HNSC (DFS)

Open the HNSC breakdown →