PRICKLE2

Across TCGA patient cohorts, PRICKLE2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRICKLE2-associated genes across cancer lineages are ATM, EGFR_pY1068, and p27_pT157. Each is linked with PRICKLE2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRICKLE2-to-partner and partner-to-PRICKLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PRICKLE2-low versus PRICKLE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE2→partner) and Y-score (partner→PRICKLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.372	-2.401	.004	.002	3	4
UCEC	EGFR_pY1068 →	-0.194	-1.736	.007	.006	3	3
LUSC	p27_pT157 →	+0.200	+3.206	<.001	.008	3	2
LUSC	Annexin_VII →	+0.150	+3.197	.006	.009	3	2
STAD	p90 RSK →	+0.349	+3.000	.001	.034	3	2
STAD	Caspase-7-cleavedD198 →	+1.194	+3.321	<.001	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by PRICKLE2 expression — UCEC

Explore this box plot interactively →