PRICKLE2

Across TCGA cell cohorts, PRICKLE2 RNA expression is significantly associated with the RNA expression of many other genes, with 9,141 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRICKLE2-associated genes across cancer lineages are FOSL2, ZFYVE1, and PPP2R3A. Each is linked with PRICKLE2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PRICKLE2-to-partner and partner-to-PRICKLE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRICKLE2 versus FOSL2 in BONE, with a Pearson correlation of 0.70.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE2→partner) and Y-score (partner→PRICKLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FOSL2 →	+4.131	+2.684	<.001	<.001	3	9
SOFT_TISSUE	ZFYVE1 →	+0.832	+1.387	<.001	<.001	2	9
BONE	PPP2R3A →	+1.844	+2.257	<.001	<.001	3	8
SOFT_TISSUE	TNC →	+5.146	+1.348	<.001	<.001	3	8
BONE	GALNT10 →	+2.415	+2.607	<.001	<.001	3	7
SOFT_TISSUE	PDCD1LG2 →	+1.751	+1.125	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,141 associations by consensus.

PRICKLE2 vs FOSL2 — BONE

Explore this scatter interactively →