PRICKLE2

Across TCGA cell cohorts, PRICKLE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,713 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRICKLE2-associated GO terms across cancer lineages are Positive regulation of cell-substrate junction organization, Regulation of intracellular transport, and Golgi vesicle transport. Each is linked with PRICKLE2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PRICKLE2-to-partner and partner-to-PRICKLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate junction organization grouped by PRICKLE2-low versus PRICKLE2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE2→partner) and Y-score (partner→PRICKLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-substrate junction organization →	+0.205	+1.779	<.001	.001	3	12
BONE	Regulation of intracellular transport →	+0.072	+2.082	<.001	.003	3	11
SOFT_TISSUE	Golgi vesicle transport →	+0.064	+1.265	<.001	<.001	3	11
SOFT_TISSUE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.098	+1.551	<.001	<.001	3	11
BONE	Positive regulation of focal adhesion assembly →	+0.186	+1.947	<.001	<.001	3	11
LUNG_SCLC	Positive regulation of intracellular transport →	+0.059	+1.183	<.001	<.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,713 associations by consensus.

Positive regulation of cell-substrate junction organization by PRICKLE2 expression — BONE

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