PRICKLE2

Across TCGA cell cohorts, PRICKLE2 mutation is significantly associated with the drug of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRICKLE2-associated genes across cancer lineages are KIN001-236, AZD7762, and Tanespimycin. Each is linked with PRICKLE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRICKLE2-to-partner and partner-to-PRICKLE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIN001-236 grouped by PRICKLE2-low versus PRICKLE2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE2→partner) and Y-score (partner→PRICKLE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KIN001-236 →	+0.281	+2.662	.035	.042	3	1
LARGE_INTESTINE	AZD7762 →	+0.612	+3.061	.007	.010	3	1
LARGE_INTESTINE	Tanespimycin →	+0.543	+2.807	.027	.046	3	1
LARGE_INTESTINE	NU7441 →	+0.458	+2.807	.024	.046	3	1
LARGE_INTESTINE	Wee1 Inhibitor →	+0.516	+2.871	.039	.021	3	1
LARGE_INTESTINE	CCT245467 →	+0.558	+2.807	.007	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

KIN001-236 by PRICKLE2 expression — SKIN

Explore this box plot interactively →