PRICKLE1

Across TCGA pan-cancer cohorts, PRICKLE1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PRICKLE1 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher PRICKLE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRICKLE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LIHC, STAD, and UCEC are the cancer types where PRICKLE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.059	0.775	<.001	27	view →
STAD	OS	Median	III,IV	0.327	0.643	.006	24	view →
UCEC	DFS	Median	II,III,IV	0.922	0.436	.023	12	view →
HNSC	OS	Median	All	0.191	0.710	.021	9	view →
PAAD	OS	Median	All	0.132	0.640	.018	6	view →
ESCA	OS	Median	All	0.261	0.704	.004	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PRICKLE1–LIHC (OS)

Open the LIHC breakdown →