PRICKLE1

Across TCGA pan-cancer cohorts, PRICKLE1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRICKLE1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PRICKLE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRICKLE1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

LSCC, PDAC, and GBM are the cancer types where PRICKLE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.548	0.949	.003	42	view →
PDAC	OS	Quartile	All	1.000	0.564	.001	22	view →
GBM	DFS	Median	All	0.810	0.580	.020	6	view →
LUAD	DFS	Tertile	All	0.750	0.368	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRICKLE1–LSCC (DFS)

Open the LSCC breakdown →