PRICKLE1

Across TCGA patient cohorts, PRICKLE1 mutation is significantly associated with the RNA expression of many other genes, with 2,896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRICKLE1-associated genes across cancer lineages are UBE2D3P4, MTND3P24, and RNA5SP419. Each is linked with PRICKLE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRICKLE1-to-partner and partner-to-PRICKLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2D3P4 grouped by PRICKLE1-low versus PRICKLE1-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE1→partner) and Y-score (partner→PRICKLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	UBE2D3P4 →	+0.089	+7.939	<.001	.008	3	3
LUAD	MTND3P24 →	+0.166	+4.786	<.001	.003	3	3
UCEC	RNA5SP419 →	+0.469	+1.829	<.001	.004	3	3
STAD	PTN →	-1.132	-3.426	.002	.005	3	3
STAD	RPSAP28 →	+0.167	+3.609	.007	.001	3	3
UCEC	ARPC5 →	+0.357	+1.807	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,896 associations by consensus.

UBE2D3P4 by PRICKLE1 expression — PRAD

Explore this box plot interactively →