PRICKLE1

Across TCGA patient cohorts, PRICKLE1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRICKLE1-associated genes across cancer lineages are PARP_cleaved, Notch1, and Cyclin-B1. Each is linked with PRICKLE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRICKLE1-to-partner and partner-to-PRICKLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARP_cleaved grouped by PRICKLE1-low versus PRICKLE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE1→partner) and Y-score (partner→PRICKLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PARP_cleaved →	+0.148	+2.000	.033	.031	3	3
UCEC	Notch1 →	+0.216	+2.232	<.001	.005	3	3
UCEC	Cyclin-B1 →	+0.570	+1.502	.005	.030	3	3
LUSC	Di-Ras3 →	+0.173	+3.013	<.001	.018	3	2
SKCM	JNK2 →	-0.262	-3.000	.004	.034	3	2
SKCM	MEK1 →	-0.500	-3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PARP_cleaved by PRICKLE1 expression — SKCM

Explore this box plot interactively →