PRICKLE1

Across TCGA cell cohorts, PRICKLE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,440 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRICKLE1-associated GO terms across cancer lineages are Tear secretion, Protein stabilization, and Cornea development in camera-type eye. Each is linked with PRICKLE1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PRICKLE1-to-partner and partner-to-PRICKLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tear secretion grouped by PRICKLE1-low versus PRICKLE1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE1→partner) and Y-score (partner→PRICKLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Tear secretion →	+1.692	+1.902	<.001	<.001	3	20
STOMACH	Protein stabilization →	+0.075	+2.068	<.001	.003	3	14
KIDNEY	Cornea development in camera-type eye →	+1.618	+2.146	<.001	<.001	3	13
KIDNEY	Primitive streak formation →	+1.737	+2.638	<.001	<.001	3	12
BONE	Transforming growth factor beta receptor signaling pathway →	+0.073	+1.303	<.001	<.001	3	11
BREAST	Negative regulation of myoblast fusion →	+0.113	+1.534	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,440 associations by consensus.

Tear secretion by PRICKLE1 expression — PANCREAS

Explore this box plot interactively →