PRICKLE1

Across TCGA cell cohorts, PRICKLE1 mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRICKLE1-associated genes across cancer lineages are MAGEB4, SRARP, and PAK5. Each is linked with PRICKLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRICKLE1-to-partner and partner-to-PRICKLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PRICKLE1-low versus PRICKLE1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE1→partner) and Y-score (partner→PRICKLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MAGEB4 →	+0.011	+4.643	<.001	.003	3	1
CNS	SRARP →	+0.054	+4.315	<.001	.006	3	1
SKIN	PAK5 →	+0.083	+4.362	<.001	.005	3	1
SKIN	CCR6 →	+0.031	+4.347	<.001	.001	3	1
SKIN	DEFB108B →	+0.028	+4.437	<.001	.004	3	1
SKIN	MBD3L2 →	+0.271	+3.793	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

MAGEB4 by PRICKLE1 expression — CNS

Explore this box plot interactively →