PRH1

Across TCGA patient cohorts, PRH1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRH1-associated genes across cancer lineages are MEK1, AMPK_alpha, and S6_pS240_S244. Each is linked with PRH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRH1-to-partner and partner-to-PRH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PRH1-low versus PRH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRH1→partner) and Y-score (partner→PRH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.682	+3.169	<.001	.019	3	1
UCEC	AMPK_alpha →	-0.221	-3.169	.034	.020	3	1
UCEC	S6_pS240_S244 →	+0.501	+3.169	.024	.020	3	1
UCEC	STAT3_pY705 →	-0.406	-2.999	.004	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.219	-3.156	.017	.020	1	1
UCEC	PDCD4 →	-0.637	-3.169	.013	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1 by PRH1 expression — UCEC

Explore this box plot interactively →