PRH1

Across TCGA cell cohorts, PRH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,357 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRH1-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Heterochromatin formation, and Protein desumoylation. Each is linked with PRH1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRH1-to-partner and partner-to-PRH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by PRH1-low versus PRH1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRH1→partner) and Y-score (partner→PRH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.078	+0.949	<.001	.007	3	10
LUNG_NSCLC_LUSC	Heterochromatin formation →	+0.091	+1.202	<.001	.006	3	9
BLOOD_Leukemia	Protein desumoylation →	+0.068	+0.372	<.001	<.001	3	9
BLOOD_Myeloma	Phosphatidylinositol dephosphorylation →	+0.055	+0.896	.001	.002	3	8
LUNG_NSCLC_LUSC	Regulation of microtubule-based process →	+0.062	+0.998	.002	.005	3	7
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.064	+1.021	<.001	.005	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,357 associations by consensus.

Negative regulation of gene expression, epigenetic by PRH1 expression — LUNG_NSCLC_LUSC

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