Across TCGA patient cohorts, PRG2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRG2-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK2, and MEK1. Each is linked with PRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRG2-to-partner and partner-to-PRG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG2→partner) and Y-score (partner→PRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.789	+3.019	.008	.019	3	2
UCEC	JNK2 →	+0.292	+3.459	.003	.005	3	1
UCEC	MEK1 →	+0.460	+3.459	.012	.005	3	1
UCEC	Notch1 →	+0.189	+2.179	.007	.034	3	1
UCEC	STAT5a →	+0.469	+2.321	.019	.035	3	1
UCEC	Tuberin →	+0.335	+3.009	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

PRG2 survival (RNA) · tumor vs normal (RNA) · all PRG2 data types