PRF1

Across TCGA pan-cancer cohorts, PRF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRF1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PRF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PRF1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where PRF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.873	0.593	<.001	41	view →
LUAD	OS	Median	II,III,IV	0.850	0.404	.008	15	view →
HNSC	DFS	Median	III,IV	0.720	0.484	.006	13	view →
OV	DFS	Tertile	All	0.494	1.000	.026	4	view →
UCEC	DFS	Median	II,III,IV	0.518	0.882	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PRF1–CCRCC (DFS)

Open the CCRCC breakdown →