PRF1

Across TCGA patient cohorts, PRF1 mutation is significantly associated with the RNA expression of many other genes, with 3,767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRF1-associated genes across cancer lineages are UBE2F-SCLY, PBK, and UBE2T. Each is linked with PRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRF1-to-partner and partner-to-PRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2F-SCLY grouped by PRF1-low versus PRF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRF1→partner) and Y-score (partner→PRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UBE2F-SCLY →	+0.050	+2.583	<.001	.001	3	3
UCEC	PBK →	+0.939	+2.818	<.001	<.001	3	3
UCEC	UBE2T →	+0.691	+2.364	<.001	<.001	3	3
HNSC	SNORD66 →	+0.447	+4.565	.004	.004	3	3
UCEC	BCCIP →	+0.466	+2.955	<.001	<.001	3	3
UCEC	GOT1 →	+0.350	+2.439	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,767 associations by consensus.

UBE2F-SCLY by PRF1 expression — SKCM

Explore this box plot interactively →