PRF1

Across TCGA patient cohorts, PRF1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRF1-associated genes across cancer lineages are Cyclin-B1, Ku80, and TFRC. Each is linked with PRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRF1-to-partner and partner-to-PRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PRF1-low versus PRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRF1→partner) and Y-score (partner→PRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.542	+2.584	.008	.010	3	3
UCEC	Ku80 →	+0.273	+1.861	.001	.005	3	2
STAD	TFRC →	+0.799	+3.169	.009	.019	2	2
STAD	TIGAR →	+0.494	+3.169	.014	.019	3	1
STAD	53BP1 →	+0.437	+3.169	.025	.019	2	2
UCEC	eIF4E →	+0.158	+3.013	.041	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Cyclin-B1 by PRF1 expression — UCEC

Explore this box plot interactively →