PRF1

Across TCGA cell cohorts, PRF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,095 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRF1-associated GO terms across cancer lineages are Regulation of telomere maintenance, Import across plasma membrane, and Mast cell activation involved in immune response. Each is linked with PRF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PRF1-to-partner and partner-to-PRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance grouped by PRF1-low versus PRF1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRF1→partner) and Y-score (partner→PRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of telomere maintenance →	+0.039	+0.061	.004	.007	2	6
OESOPHAGUS	Import across plasma membrane →	-0.051	-0.078	.003	.003	3	5
BLOOD_Lymphoma	Mast cell activation involved in immune response →	-0.150	-3.080	<.001	<.001	3	5
BLOOD_Lymphoma	Mast cell degranulation →	-0.150	-3.080	<.001	<.001	3	5
BLOOD_Leukemia	Immunological synapse formation →	-0.198	-1.573	<.001	<.001	3	4
BLOOD_Leukemia	Regulation of T-helper 17 cell lineage commitment →	+0.127	+1.556	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,095 associations by consensus.

Regulation of telomere maintenance by PRF1 expression — BREAST

Explore this box plot interactively →