PRF1

Across TCGA cell cohorts, PRF1 mutation is significantly associated with the RNA expression of many other genes, with 245 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRF1-associated genes across cancer lineages are CNOT10, CCR8, and UTP18. Each is linked with PRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRF1-to-partner and partner-to-PRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNOT10 grouped by PRF1-low versus PRF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRF1→partner) and Y-score (partner→PRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNOT10 →	+0.390	+3.199	.006	.007	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
LARGE_INTESTINE	UTP18 →	+0.474	+2.472	.003	.008	3	1
LARGE_INTESTINE	ZNF639 →	+0.569	+3.364	.005	.002	3	1
LARGE_INTESTINE	ACO1 →	+0.722	+3.364	.002	.002	3	1
LARGE_INTESTINE	NDUFAF4 →	+0.641	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 245 associations by consensus.

CNOT10 by PRF1 expression — BLOOD_Leukemia

Explore this box plot interactively →