PREX1

Across TCGA pan-cancer cohorts, PREX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PREX1 data layer compared with 28 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PREX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PREX1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where PREX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.833	1.000	.013	72	view →
LUAD	DFS	Quartile	All	0.836	0.372	.003	13	view →
PDAC	OS	Median	II,III,IV	0.694	0.947	.006	7	view →
CCRCC	DFS	Median	II,III,IV	0.735	0.478	.009	6	view →
HNSC	DFS	Quartile	All	0.898	1.000	.018	4	view →
GBM	OS	Tertile	All	0.567	0.292	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PREX1–COAD (DFS)

Open the COAD breakdown →