PREX1

Across TCGA patient cohorts, PREX1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,296 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PREX1-associated genes across cancer lineages are ARHGEF6, GAB3, and RHOH. Each is linked with PREX1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PREX1-to-partner and partner-to-PREX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PREX1 versus ARHGEF6 in HNSC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX1→partner) and Y-score (partner→PREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGEF6 →	+0.832	+0.391	<.001	<.001	3	10
HNSC	GAB3 →	+0.811	+0.405	<.001	<.001	3	9
BRCA	RHOH →	+1.237	+0.580	<.001	.001	3	9
GBM	ABCD2 →	+0.893	+0.359	.004	.009	3	9
LSCC	TLR10 →	+1.056	+0.389	<.001	<.001	3	9
LSCC	SHISAL2A →	+0.741	+0.408	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,296 associations by consensus.

PREX1 vs ARHGEF6 — HNSC

Explore this scatter interactively →