PREX1

Across TCGA patient cohorts, PREX1 mutation is significantly associated with the RNA expression of many other genes, with 5,792 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PREX1-associated genes across cancer lineages are NDUFAF5, RNA5SP411, and AURKA. Each is linked with PREX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PREX1-to-partner and partner-to-PREX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by PREX1-low versus PREX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX1→partner) and Y-score (partner→PREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDUFAF5 →	+0.361	+2.153	.005	.009	3	5
UCEC	RNA5SP411 →	+0.766	+1.493	<.001	.001	3	5
UCEC	AURKA →	+0.480	+2.290	.005	<.001	3	5
UCEC	RFC5 →	+0.477	+2.010	<.001	.001	3	4
SKCM	MASTL →	+0.544	+2.713	.004	.003	3	4
SKCM	STIL →	+0.511	+2.610	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,792 associations by consensus.

NDUFAF5 by PREX1 expression — SKCM

Explore this box plot interactively →