PREX1

Across TCGA patient cohorts, PREX1 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PREX1-associated genes across cancer lineages are PCNA, ATM, and Caspase-7-cleavedD198. Each is linked with PREX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PREX1-to-partner and partner-to-PREX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PREX1-low versus PREX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX1→partner) and Y-score (partner→PREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.326	+2.708	.001	.003	3	3
UCEC	ATM →	-0.614	-2.050	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.313	+3.815	<.001	<.001	3	3
COAD	PKC-delta_pS664 →	-0.147	-1.991	.006	.031	3	3
LUSC	GATA3 →	-0.162	-3.779	.024	<.001	3	2
BRCA	4E-BP1 →	+0.375	+3.183	.038	.010	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

PCNA by PREX1 expression — COAD

Explore this box plot interactively →