PREX1

Across TCGA cell cohorts, PREX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,484 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PREX1-associated GO terms across cancer lineages are Nucleotide biosynthetic process, DNA-templated transcription initiation, and Transcription initiation at RNA polymerase II promoter. Each is linked with PREX1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PREX1-to-partner and partner-to-PREX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleotide biosynthetic process grouped by PREX1-low versus PREX1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX1→partner) and Y-score (partner→PREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Nucleotide biosynthetic process →	+0.100	+1.811	<.001	<.001	3	10
PANCREAS	DNA-templated transcription initiation →	+0.066	+1.722	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.073	+1.283	<.001	<.001	3	9
BONE	Transcription initiation at RNA polymerase III promoter →	+0.091	+1.935	<.001	.001	3	9
SOFT_TISSUE	Protein-DNA complex assembly →	+0.085	+2.900	<.001	<.001	3	9
BONE	Protein-DNA complex organization →	+0.072	+2.198	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,484 associations by consensus.

Nucleotide biosynthetic process by PREX1 expression — OESOPHAGUS

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