PREX1

Across TCGA cell cohorts, PREX1 mutation is significantly associated with the RNA expression of many other genes, with 619 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PREX1-associated genes across cancer lineages are FSHR, DENND10, and RWDD3. Each is linked with PREX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PREX1-to-partner and partner-to-PREX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHR grouped by PREX1-low versus PREX1-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX1→partner) and Y-score (partner→PREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FSHR →	+0.310	+4.459	<.001	.001	3	2
LARGE_INTESTINE	DENND10 →	+0.626	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	RWDD3 →	+0.387	+3.321	.001	.002	3	2
LARGE_INTESTINE	RPP40 →	+0.455	+3.307	.008	.003	2	3
LARGE_INTESTINE	SRMS →	+0.762	+2.000	.002	.009	3	2
LUNG_NSCLC_LUAD	POMGNT2 →	+0.573	+2.621	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 619 associations by consensus.

FSHR by PREX1 expression — LIVER

Explore this box plot interactively →