PREPL

Across TCGA pan-cancer cohorts, PREPL mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PREPL data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PREPL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PREPL expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where PREPL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.781	0.978	.001	41	view →
LSCC	DFS	Quartile	All	0.583	0.858	.014	5	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.314	.024	2	view →
PDAC	OS	Median	III,IV	1.000	0.589	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PREPL–CCRCC (OS)

Open the CCRCC breakdown →