PREPL

Across TCGA pan-cancer cohorts, PREPL mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PREPL’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PREPL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PREPL is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

CCRCC, LSCC, and HNSC are the cancer types where PREPL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PREPL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.192	<.001	12	view →
LSCC	All	All	−0.171	<.001	7	view →
HNSC	Male	All	−0.288	<.001	6	view →
PDAC	Female	II,III,IV	−0.271	<.001	6	view →
COAD	Female	II,III,IV	−0.165	.006	6	view →
LUAD	All	All	+0.114	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PREPL–CCRCC

Open the CCRCC breakdown →