PREPL

Across TCGA patient cohorts, PREPL protein abundance is significantly associated with the RNA expression of many other genes, with 10,210 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PREPL-associated genes across cancer lineages are GBP5, APOBEC3A, and TBX21. Each is linked with PREPL in more than 4 cancer types. Because this analysis shows association rather than direction, both PREPL-to-partner and partner-to-PREPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PREPL versus GBP5 in LUAD, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREPL→partner) and Y-score (partner→PREPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GBP5 →	-1.026	-0.230	<.001	.001	3	5
LSCC	APOBEC3A →	-1.139	-0.241	<.001	<.001	3	4
BRCA	TBX21 →	-0.634	-0.252	<.001	.001	3	4
BRCA	MCM5 →	-0.782	-0.266	<.001	<.001	3	4
HNSC	PPP1R1A →	+0.649	+0.374	.004	<.001	3	4
BRCA	TMEM63C →	+1.292	+0.254	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,210 associations by consensus.

PREPL vs GBP5 — LUAD

Explore this scatter interactively →