PREPL

Across TCGA patient cohorts, PREPL mutation is significantly associated with the RNA expression of many other genes, with 3,345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PREPL-associated genes across cancer lineages are OR52E7P, H2BC17, and H2AC14. Each is linked with PREPL in more than 2 cancer types. Because this analysis shows association rather than direction, both PREPL-to-partner and partner-to-PREPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E7P grouped by PREPL-low versus PREPL-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREPL→partner) and Y-score (partner→PREPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR52E7P →	+0.065	+5.706	<.001	.003	3	3
UCEC	H2BC17 →	+0.588	+2.069	.005	<.001	3	2
UCEC	H2AC14 →	+0.940	+2.058	<.001	<.001	3	2
HNSC	OR51G2 →	+0.036	+5.763	<.001	.001	3	2
HNSC	RNU6-1104P →	+0.364	+5.468	<.001	.002	3	2
HNSC	RN7SKP144 →	+0.129	+5.339	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,345 associations by consensus.

OR52E7P by PREPL expression — LUSC

Explore this box plot interactively →