PREPL

Across TCGA patient cohorts, PREPL mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PREPL-associated genes across cancer lineages are eIF4E, p21, and PREX1. Each is linked with PREPL in more than 1 cancer types. Because this analysis shows association rather than direction, both PREPL-to-partner and partner-to-PREPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PREPL-low versus PREPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREPL→partner) and Y-score (partner→PREPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.144	+2.335	.049	.018	3	2
UCEC	p21 →	+0.241	+2.459	<.001	<.001	3	2
UCEC	PREX1 →	-0.192	-2.115	.043	.017	3	2
SKCM	PKC-delta_pS664 →	-0.363	-3.000	<.001	.036	3	1
SKCM	PR →	+0.125	+3.000	.015	.036	3	1
SKCM	TSC1 →	-0.267	-3.000	.024	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eIF4E by PREPL expression — UCEC

Explore this box plot interactively →