PREPL

Across TCGA cell cohorts, PREPL mutation is significantly associated with the mutation status of many other genes, with 5,026 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PREPL-associated genes across cancer lineages are MTNR1B, ATG2A, and HMGCLL1. Each is linked with PREPL in more than 4 cancer types. Because this analysis shows association rather than direction, both PREPL-to-partner and partner-to-PREPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTNR1B grouped by PREPL-low versus PREPL-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREPL→partner) and Y-score (partner→PREPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MTNR1B →	+4.857	+4.297	.009	.009	1	5
SKIN	ATG2A →	+2.977	+4.392	.005	.005	1	4
BLOOD_Lymphoma	HMGCLL1 →	+6.014	+6.014	.001	.001	1	4
BREAST	ADCY1 →	+4.442	+5.095	.001	.001	1	4
OVARY	SYNM →	+4.415	+4.977	.007	.007	1	4
OVARY	IL1RL2 →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,026 associations by consensus.

MTNR1B by PREPL expression — BREAST

Explore this box plot interactively →