PREP

Across TCGA pan-cancer cohorts, PREP Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PREP data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PREP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PREP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, OV, and BLCA are the cancer types where PREP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.300	0.744	<.001	20	view →
OV	OS	Median	II,III,IV	0.395	0.692	.041	18	view →
BLCA	OS	Median	IV	0.130	0.599	.002	12	view →
LUSC	OS	Median	III,IV	0.112	0.664	.003	12	view →
UCEC	DFS	Median	II,III,IV	0.928	0.435	.018	8	view →
SARC	OS	Median	All	0.174	0.860	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PREP–SKCM (OS)

Open the SKCM breakdown →