PREP

Across TCGA pan-cancer cohorts, PREP mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PREP’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PREP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PREP is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

CCRCC, COAD, and LSCC are the cancer types where PREP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PREP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.180	<.001	11	view →
COAD	All	II,III,IV	−0.216	.005	6	view →
LSCC	All	All	+0.117	<.001	4	view →
LUAD	All	All	−0.078	.001	4	view →
OV	All	All	+0.355	.009	2	view →
PDAC	Female	All	−0.162	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PREP–CCRCC

Open the CCRCC breakdown →